Name | (2R,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexanoic acid |
Synonyms | D-Gulonicaci Gulonic acid (2R,3R,4S,5R)-2,3,4,5,6-pentahydroxyhexanoic acid |
CAS | 20246-53-1 |
Molecular Formula | C6H12O7 |
Molar Mass | 196.16 |
Density | 1.763±0.06 g/cm3(Predicted) |
Boling Point | 673.6±55.0 °C(Predicted) |
pKa | 3.35±0.35(Predicted) |
Use | Use 1. Gulonic acid is used as vitamin C intermediate. 2, used as a vitamin Intermediate |
CN200410051754.6
application date:
September 28, 2004
Public/Announcement Number:
CN1754869
applicant (patent):
Sanda membrane technology (Xiamen) Co., Ltd.
inventor:
blue fluorescence , Huang Songqing
National and provincial code:
Fujian
cited:
Abstract:
The invention discloses a method for extracting gulonic acid, which comprises the following steps: a, filtering the fermentation broth directly into an ultrafiltration membrane system to remove proteins, hyphae, suspended substances, colloids, bacteria and other macromolecular organic matter in the filter residue; B, ultrafiltrate containing gulonic acid sodium salt enters the continuous ion exchange system to convert gulonic acid into gulonic acid; c, gulonic acid solution is pre-concentrated by nanofiltration membrane system; d, the concentrated solution is concentrated by thin film evaporation, and then after secondary concentration, the crystals of gulonic acid are obtained by crystallization. The invention can reduce consumption, increase yield, improve quality, reduce pollution and simplify operation.
sovereignty:
1. a method for extracting gulonic acid, characterized in that the steps are: a, filtering the fermentation broth directly into the ultrafiltration membrane system, remove proteins, hyphae, suspended , colloids, bacteria and other macromolecular organics in the filter residue; B. The ultrafiltrate containing gulonic acid sodium salt enters the continuous ion exchange system, convert gulonic acid into gulonic acid ; c and gulonic acid solution are pre-concentrated by nanofiltration membrane system; d, the concentrated solution is concentrated by thin film evaporation, and then subjected to secondary concentration and crystallization to obtain Gulong acid crystals.
CN201410608595.9
application date:
2014-11-04
Public/Announcement Number:
CN104383813B
Public/announcement date:
2017.05.31
applicant (patent):
DSM Jiangshan Pharmaceutical (Jiangsu) Co., Ltd.
inventor:
Cao Yunfeng , Chang Xiaohua , Zhu Yan , Zhao emming
National and provincial code:
CN321282
Abstract:
The invention provides a comprehensive treatment method for gulonic acid fermentation broth. The gulonic acid fermentation broth is filtered by an organic membrane, and the residue is filtered by a ceramic membrane to achieve further concentration. After the filtrate is filtered out, the residue is washed with water, and all the filtrates filtered by the ceramic membrane are combined, then through the organic membrane filtration treatment, to ensure the removal of protein, ceramic membrane slag through the scraper drying to make feed protein. Compared with the prior art, the present invention reduces the amount of washing water, improves the quality of the filtrate, improves the concentration of gulonic acid in the filtrate, achieves the total ultrafiltration yield of more than 98.92%, simultaneously realizes the concentration of the slag, and the solid content of the ceramic membrane slag is 1520%, the scraper drying was used to directly process the feed protein, which realized the comprehensive utilization of the slag liquid and greatly reduced the emission of the three wastes.
Uses | Gulonic acid is used as an intermediate of vitamin C. Used as a vitamin intermediate |